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Page 1
NKG7 Is a T-cell-Intrinsic Therapeutic Target for Improving Antitumor Cytotoxicity and Cancer Immunotherapy.
Wen T, Barham W, Li Y, Zhang H, Gicobi JK, Hirdler JB, Liu X, Ham H, Peterson Martinez KE, Lucien F, Lavoie RR, Li H, Correia C, Monie DD, An Z, Harrington SM, Wu X, Guo R, Dronca RS, Mansfield AS, Yan Y, Markovic SN, Park SS, Sun J, Qin H, Liu MC, Vasmatzis G, Billadeau DD, Dong H. Wen T, et al. Cancer Immunol Res. 2022 Feb;10(2):162-181. doi: 10.1158/2326-6066.CIR-21-0539. Epub 2021 Dec 15. Cancer Immunol Res. 2022. PMID: 34911739 Free PMC article.
NKG7 mRNA therapy also improved the antitumor activity of murine tumor antigen-specific CD8(+) T cells in an in vivo model of adoptive cell therapy. Finally, we showed that the transcription factor ETS1 played a role in regulating NKG7 expression. Together, our resu …
NKG7 mRNA therapy also improved the antitumor activity of murine tumor antigen-specific CD8(+) T cells in an in vivo model of adoptiv …
NKG7 Is Required for Optimal Antitumor T-cell Immunity.
Li XY, Corvino D, Nowlan B, Aguilera AR, Ng SS, Braun M, Cillo AR, Bald T, Smyth MJ, Engwerda CR. Li XY, et al. Cancer Immunol Res. 2022 Feb;10(2):154-161. doi: 10.1158/2326-6066.CIR-20-0649. Epub 2022 Jan 10. Cancer Immunol Res. 2022. PMID: 35013002
However, aside from these correlative observations, very little is known about NKG7 and its role in antitumor immunity. Herein, we utilized single-cell RNA sequencing (scRNA-seq) datasets, NKG7-deficient mice, NKG7-reporter mice, and mouse tumor models to inv …
However, aside from these correlative observations, very little is known about NKG7 and its role in antitumor immunity. Herein, we ut …
Tumor microenvironment gene expression profiles associated to complete pathological response and disease progression in resectable NSCLC patients treated with neoadjuvant chemoimmunotherapy.
Casarrubios M, Provencio M, Nadal E, Insa A, Del Rosario García-Campelo M, Lázaro-Quintela M, Dómine M, Majem M, Rodriguez-Abreu D, Martinez-Marti A, De Castro Carpeño J, Cobo M, López Vivanco G, Del Barco E, Bernabé R, Viñolas N, Barneto Aranda I, Massuti B, Sierra-Rodero B, Martinez-Toledo C, Fernández-Miranda I, Serna-Blanco R, Romero A, Calvo V, Cruz-Bermúdez A. Casarrubios M, et al. J Immunother Cancer. 2022 Sep;10(9):e005320. doi: 10.1136/jitc-2022-005320. J Immunother Cancer. 2022. PMID: 36171009 Free PMC article. Clinical Trial.
RESULTS: CPR tumors had a stronger pre-established immune infiltrate at baseline than non-CPR, characterized by higher levels of IFNG, GZMB, NKG7, and M1 macrophages, all with a significant area under the receiver operating characteristic curve (ROC) >0.9 for CPR predic …
RESULTS: CPR tumors had a stronger pre-established immune infiltrate at baseline than non-CPR, characterized by higher levels of IFNG, GZMB, …
Multi-omic features of oesophageal adenocarcinoma in patients treated with preoperative neoadjuvant therapy.
M Naeini M, Newell F, Aoude LG, Bonazzi VF, Patel K, Lampe G, Koufariotis LT, Lakis V, Addala V, Kondrashova O, Johnston RL, Sharma S, Brosda S, Holmes O, Leonard C, Wood S, Xu Q, Thomas J, Walpole E, Tao Mai G, Ackland SP, Martin J, Burge M, Finch R, Karapetis CS, Shannon J, Nott L, Bohmer R, Wilson K, Barnes E, Zalcberg JR, Mark Smithers B, Simes J, Price T, Gebski V, Nones K, Watson DI, Pearson JV, Barbour AP, Waddell N. M Naeini M, et al. Nat Commun. 2023 May 31;14(1):3155. doi: 10.1038/s41467-023-38891-x. Nat Commun. 2023. PMID: 37258531 Free PMC article.
The immune hot cluster is associated with better survival, enriched with lymphocytes, myeloid-derived cells, and an immune signature including CCL5, CD8A, and NKG7. The immune clusters highlight patients who may respond to immunotherapy and thus may guide future clinical t …
The immune hot cluster is associated with better survival, enriched with lymphocytes, myeloid-derived cells, and an immune signature includi …
NKG7 Enhances CD8+ T Cell Synapse Efficiency to Limit Inflammation.
Lelliott EJ, Ramsbottom KM, Dowling MR, Shembrey C, Noori T, Kearney CJ, Michie J, Parish IA, Jordan MA, Baxter AG, Young ND, Brennan AJ, Oliaro J. Lelliott EJ, et al. Front Immunol. 2022 Jul 6;13:931630. doi: 10.3389/fimmu.2022.931630. eCollection 2022. Front Immunol. 2022. PMID: 35874669 Free PMC article.
Unexpectedly, we found that highly CD8+ T cell-immunogenic murine colon carcinoma (MC38-OVA) tumors grew at an equal rate in Nkg7(+/+) and Nkg7(-/-) littermate mice, suggesting NKG7 may not be necessary for effective CD8+ T cell anti-tumor activity. Mechanist …
Unexpectedly, we found that highly CD8+ T cell-immunogenic murine colon carcinoma (MC38-OVA) tumors grew at an equal rate in Nkg7(+/+ …
CXCL9 correlates with antitumor immunity and is predictive of a favorable prognosis in uterine corpus endometrial carcinoma.
Xue S, Su XM, Ke LN, Huang YG. Xue S, et al. Front Oncol. 2023 Feb 8;13:1077780. doi: 10.3389/fonc.2023.1077780. eCollection 2023. Front Oncol. 2023. PMID: 36845675 Free PMC article.
BACKGROUND: The C-X-C motif chemokine ligand-9 (CXCL9) is related to the progression of multiple neoplasms. Yet, its biological functions in uterine corpus endometrioid carcinoma (UCEC) remain shrouded in confusion. ...RESULTS: The bioinformatics analysis suggested that CX …
BACKGROUND: The C-X-C motif chemokine ligand-9 (CXCL9) is related to the progression of multiple neoplasms. Yet, its biological funct …
Single-cell RNA sequencing reveals cellular and molecular immune profile in a Pembrolizumab-responsive PD-L1-negative lung cancer patient.
Zhong R, Zhang Y, Chen D, Cao S, Han B, Zhong H. Zhong R, et al. Cancer Immunol Immunother. 2021 Aug;70(8):2261-2274. doi: 10.1007/s00262-021-02848-0. Epub 2021 Jan 27. Cancer Immunol Immunother. 2021. PMID: 33506299 Free PMC article.
All 3423 cells of 16 clusters were classified into eight cell types, including NKG7+ T, NKG7+ NK, Naive T, CDC1C+ dendritic cells, CD8+ T cells, B cells, macrophages and erythrocytes. Cell proportion, the clinical significance of differentially expressed genes and s …
All 3423 cells of 16 clusters were classified into eight cell types, including NKG7+ T, NKG7+ NK, Naive T, CDC1C+ dendritic ce …
HDACs alters negatively to the tumor immune microenvironment in gynecologic cancers.
Yan M, Cao H, Tao K, Xiao B, Chu Y, Ma D, Huang X, Han Y, Ji T. Yan M, et al. Gene. 2023 Nov 15;885:147704. doi: 10.1016/j.gene.2023.147704. Epub 2023 Aug 11. Gene. 2023. PMID: 37572797 Free article.
Increased HDAC expression was linked to reduced infiltration of natural killer (NK), NKT, and CD8(+) T cells, along with negative associations with the expression of PSMB10, NKG7, CCL5, CD27, HLA-DQA1, and HLA-DQB1. In a murine 4T1 breast cancer model, treatment with suber …
Increased HDAC expression was linked to reduced infiltration of natural killer (NK), NKT, and CD8(+) T cells, along with negative associatio …
Understanding Suboptimal Response to Immune Checkpoint Inhibitors.
Zhu M, Zhang H, Pedersen KS, Foster NR, Jaszewski BL, Liu X, Hirdler JB, An Z, Bekaii-Saab TS, Halfdanarson TR, Boland PM, Yan Y, Hubbard JH, Ma WW, Yoon HH, Revzin A, Fernandez-Zapico ME, Overman MJ, McWilliams RR, Dong H. Zhu M, et al. Adv Biol (Weinh). 2023 Apr;7(4):e2101319. doi: 10.1002/adbi.202101319. Epub 2022 Mar 27. Adv Biol (Weinh). 2023. PMID: 35343107
The cytolytic capacity of circulating immune cells in cancer patients using a novel ex vivo cytotoxicity assay is evaluated, and the utility of circulating biomarkers is investigated to predict and monitor the treatment effect of anti-PD-1. Baseline expression of Bim and NKG7 …
The cytolytic capacity of circulating immune cells in cancer patients using a novel ex vivo cytotoxicity assay is evaluated, and the utility …
26 results